Saxenda Weight Loss Medicine Reviews
Saxenda is a new drug. It's basically a spin-off of Victoza, is a diabetes drug. The Saxenda is just the same exact product rebranded with a slightly different dosing to be a weight loss medication. It has the same chemical in it.
Saxenda belongs to a class of drugs called GLP-1 agonists. GLP-1 is a naturally occurring hormone in the body. These both drugs are similar to that they act in a similar way.
GLP-1 comes from the Mexican lizard saliva. Scientists discovered that the saliva had a GLP - 1 similar chemical and but when they injected it into people they found that it took a longer amount of time to break down. Human GLP - 1 is destroyed in the body within ten minutes, all of it is basically gone.
This new weight-loss drug has some pretty compelling effects this data. Over 40% of people who used Saxenda saw a 5% decrease in their weight and almost a quarter of them saw a 10% decrease in weight. That is a significant weight loss.
How Does Saxenda Work?
We knew that it is it is a side effect of Victoza that causes weight loss. And the way it does that is these drugs increase the amount of insulin that your pancreas produces, kind of in a dose-responsive way to blood sugar. They don't cause hypoglycemia as much as other diabetes drugs but another thing that they do is they cause something called delayed gastric emptying.
That's why these medications have a lot of the upset stomach type side effects. However, one of the things that they do is they also cause weight loss and they do that by causing delayed gastric emptying. All that means is that the food in your stomach stays there a little bit longer and people feel full and fuller longer. And because of that, we've seen some weight loss.
Side Effects Of Saxenda
The most significant side effect of Saxenda is nausea. If you look at the packet insert, you'll see that they have a basically a dose titration schedule.
Along with nausea you may experience vomiting, diarrhea, upset stomach. Compared to the placebo group in the 3 studies that's scientists did on Saxenda, almost 40% of patients had some nausea compared to about 14% in the placebo group. Almost 21% had diarrhea compared to 10% in the placebo group. 19% had constipation compared to 8% in the placebo group, 15% vomiting compared to 4% in the placebo group, 9% dyspepsia versus 2%.
Saxenda also has a black box warning because mice that were injected with Saxenda were found to develop thyroid cell tumors. This fact the FDA deemed to be important enough to have a black box warning. That is why this drug is not recommended for people prone to developing certain thyroid tumors.
A couple of other issues that came up in these trials were an issue with pancreatitis and gallbladder. In the study, 0.3% of patients had pancreatitis, who were treated with Saxenda versus 0.1% on the placebo group.
Similarly, there was an issue with gallstones - 2.2% of patients on Saxenda had gallstones compared to 0.8% in the placebo group. A lot of those people had to have their gallbladder out.
Unfortunately, a lot of patients who are obese and who have diabetes might experience hypoglycemia because of the drugs that they're already taking like sulfonylureas or glimepiride. Any drug that increases the amount of insulin that your pancreas is producing can cause hypoglycemia. And when you add on a drug like Saxenda it can potentiate the risk of hypoglycemia.
The other problem that came up during the study was an increased risk of thyroid cancer. Around 0.2% of patients in the Saxenda and a group had thyroid cancer versus 0% in the placebo. And 0.7% of patients in the Saxenda group developed breast cancer versus 0.2% in the placebo group.
Of course, it is not many people but it's obviously a concern. All these side effects hopefully spur some questions to ask your doctor or ask your pharmacist.
There are also a couple cases of a suicidal ideation. There were nine people out of over three thousand had suicidal ideation versus two people out of almost two thousand. That works out to be 0.3% versus 0.1%.
Those are the side effects that were pretty rare. The biggest side effect of people who used Saxenda for weight loss was related to nausea, vomiting, diarrhea. You could call it to stomach upset or gastrointestinal issues and that's why the drug has a dose titration schedule.
Buy Saxenda Online
Where to buy Saxenda online? You need to have a prescription to purchase Saxenda from your local pharmacy. However, you can google the Internet and find a lot of offshore pharmacies where you can order Saxenda online without a prescription.
What is Saxenda Price?
The price of Saxenda is different in every drugstore. The average cost of Saxenda is around $1200 for a 15ml supply (around $80 per unit).
Saxenda is basically a spin-off of a diabetes drug. It has some blood sugar lowering capacity. It has an identical chemical to Victoza (weight loss was a side effect of Victoza).
There are rare instances of a thyroid cancer and that's why they have that black box from the FDA on Saxenda.
However, it is a very promising product in the sense of it looks very effective. It could be annoying for patients who don't really want to inject themselves but some patients might not mind at all. Most people when they do start injecting themselves with something are get used to it.